The article “Stem Cell Therapy Rescues Symptoms of Alzheimer’s Disease” sourced through the University of California, San Diego was originally written by Nicole Mlynaryk. This article reports on the new study conducted by San Diego researchers using progenitor and hematopoietic cells that can differentiate into various types of blood-forming cells. The researchers transplanted those progenitor and hematopoietic cells in mice with Alzheimer which demonstrated that these cells including microglia, immune cells in the brain, could be effective in preserving cognition and memory. The researchers also demonstrated that these stem cells could reduce inflammation in the brain and lead to less build-up of β-amy-loid in the mice that received healthy stem cells as compared to the mice with Alzheimer’s. They also found that the transplantation of the new and healthy stem cells also reduced plaque build-up and memory loss that is associated with Alzheimer’s. Thus, the researchers of the study showed their work as a significant “therapeutic avenue” to prevent complications from Alzheimer’s disease.
In addition, the article titled “Stem Cell-Derived Components May Treat Underlying Causes of PCOS” sourced through the University of Chicago Medical Center was originally written by Grace Niewijk in which researchers conducted the study about Polycystic Ovary Syndrome (PCOS) and its complications. The research revolved around the treatment of PCOS, a disease of the endocrine system that affects women’s fertility, hormonal balance, and overall well-being. The researchers at the University of Chicago, building on this disorder’s causes, symptoms, and difficulty in treatment, developed a new potential treatment for PCOS. The treatment method used extracellular vesicles (EVs) which could regulate the activity of cells and genes. The EVs researchers used in the experiment are actually small packages of molecules that are released by stem cells. The researchers conducted this experiment on mice with PCOS and injected EVs, also known as exosomes, into their “blood vessels or directly into the mice’s ovaries” to restore ovarian function of mice. They found that injection of EVs improved hormonal regulation in mice with PCOS which offered “renewed hope for women battling PCOS-related fertility issues” as the EVs might deliver an anti-inflammatory protein called IL-10 to the target cells in mice with PCOS. In summary, the novel approaches in both articles through the use of stem cells offer a better way to improve the disorder of Alzheimer’s and treat the root causes of PCOS to help women with fertility problems.
References
Stem cell therapy rescues symptoms of Alzheimer’s disease. (n.d.). ScienceDaily. Retrieved November 8, 2023, from https://www.sciencedaily.com/releases/2023/08/230809164724.htm
Stem cell-derived components may treat underlying causes of PCOS. (n.d.). ScienceDaily. Retrieved November 8, 2023, from https://www.sciencedaily.com/releases/2023/09/230911165846.htm
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