The new world is the old connection that formed after the Christopher Columbus voyage in the 15th century when Europeans settlers landed on the western hemisphere of America. Columbus led four voyages in which he discovered Caribbean island, Mexico Gulf, south and central America continents as part of the new world.  The new world formed after Columbus discovery that led to the expedition of Europeans as the era of European colonization. The Columbus aim was to discover a route to East Asia, and on the journey, he discovered American region while sailing from west to Europe.
The colonization started off with first Spaniards in America. All Spaniards came to America and built houses there, some of them came from rich sources found there. Later on, franc and England also sent their explorers to the west and colonized there. The native Indians were the people found in the area discovered by Columbus. Thus named as native Indians. They were tribal people. 
Before moving on to the impact of the new world on native Indians. It is important to know the buildup of mixed cultures formed after European colonization and the relationship of native people with Europeans. The settler of Europe arrived North American region which was land to the tribal natives living there for many thousand years. The tribal natives were people with different languages, religious Beliefs, and robust people. They were mostly laborers that worked on crops, lands and traded goods for their living.
The Europeans and Indian tribe met in 1500 century when the Europeans from France and Spain landed on the east coast of the American region. The relationship of the native Indians and European settlers changed from place to place based on economic, social and political factors. The relationship dynamics of the two changed on two factors, religion, and economic gain. 
The Spanish were among the powerful monarchs, and they had strong desire to get the resources of the American land. The European settler’s major concern was to own the land as being the owner would be the symbol of strength and power. Many of the Europeans that arrived in the new world realized that it is hard to own land. The settlers from England also reached the east coast of America and colonies the land the settlers of England offered Europeans land to help them have their land in return for the plan to cross the Atlantic ocean.
The mindset of the Indians, on the other hand, was that they believed that people or the settlers could use the land for harvesting, but they cannot own the land. They did not have the idea that the colonists had a plan to confiscate the property. The relationship was amicable in the start; settlers were few as compared to the native Indians. The native indunas helped setters to build the crops and teach them the ways to live through harvesting.
The example of the friendliness among settlers and native Americas is evident from the story of the metasoma and north settler from Europe. Metasoma as the leader of the Indian tribe and he helped the settlers to help them in their survival on the land in their winters. The tribal people provided the settlers with all the food and other helpful sources of living for many years. They together enjoyed the first feast which celebrated as Thanksgiving. But later on, the consequence of the settlers invasion into the tribal land brought the kind of European disease that resulted in the death of metasomas brother. The friendly relation shifted into the relationship of fear and mistrust; the familiar scenario wrecked and deformed after the majority settlers took control over the land of the native Indians. The relationship of peace turned into dismal and violence bringing the death of 3000 Native Americans death and 600 settlers in 1665 violent war. 
The effect of the new world on the Indians based on the settlements that the settlers made. The Spaniards established military points or posts in the North American region which now named as San.Augustine. The major impact of the colonization on the Indians was on the change of religion. Settlers were all Christians, and they wanted to change the religion of Native Americans as well. Some of the Farmers that worked for Spaniards converted by Catholic missionaries into Christians. San Augustin got famous for the cultural blends, inter-marriages between the Spaniards and the Indian women used to happen there. The old tribal Americans were faithful and closed to nature. They chose to stick to their own religious beliefs. 
The French settlers took advantage of the rivalries and conflicts between the tribal area people or Native Americans, and they used it for their benefits by starting trade exchange across the lake with tribes like Huron, Montagnais. The Native Americans used to capture animals and were famous for stripping off their skin and trading the fur with the French people. The French priests were cunning enough to learn the art of languages of tribes, and they converted the Indians to Christianity. In the 18th Century, the competition over the trade paced up among Dutch, French and English settlers that helped the Indians economically, and diplomatically.
The next big impact of the Europeans settlers was the introduction of the various European disease syndromes among the tribe people. The Indians were close to nature, and they had weak immunity against the diseases carried by the Europeans in their regions. The diseases were measles, chicken pox, influenza, malaria, and yellow fever.  There occurred many deaths among the Indian inhabitants of the new world.
The Indian population decreased in number as an impact of the European disease. The labors got short in number which sprouts in the enslavement of the Africans on a large scale in America. The environmental change also brought by the Europeans of the new world. The pigs colonized the land where the sheep’s and beavers used to eat. Pigs ate them, and it affected in the hunting of the native animals by the native Americans for survival.
The Europeans had the knowledge of the medicines and drugs in the new world. Columbus introduced the sugarcane in his voyage. The Europeans settlers introduced the tobacco material. The tobacco sold in the region for smoking and weed. Many herbs also brought into the Native American regions.
The Europeans researched and collected the chocolate drinking recipe from England and devised a method of extraction of chocolate from cocoa beans. The Indians were nature loving people, and they spend their life with close interaction with every natural thing. They had much more knowledge about the plants and other botanical things. The European settlers took help and advantage of their expertise in cataloging the botanical species.
The European colonization had the central objective of property-owning, and they all wanted to build houses. They got the benefit of the tribal wars fought by the Indians on the American land. They trade weapons and other goods with many tribes in exchange for the labor they wanted. The labors of the native Americans were expert and hardworking. The Europeans paid for the tribal slaves in the tribal wars for the construction of their properties.
The Indian American was unaware of the mindset that every settler took with the colonization. They welcomed the immigrants, but after the boom of the settlers around 16-18th century, the factors like trade, political power, and property ownership changes the geographic and living conditions of the native Americans.
The native Americans faced enslavement, hunger, inhumane behavior, and death toll after the colonization of the Europeans in the new world discovered by the Christopher colobus voyage to the east coast of America. They not only targeted the Indians for their food and property. They also considered them as evil or devilish creatures who did not believe in Christianity. The tribal people killed for their own religious beliefs. Many native Indians got converted by the Christians priests. With the passage of time after the 18th century, the colonization by the Dutch, Spaniards, and French took control of the America and the Indian population reduced to a minority.
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