Type 1 diabetes
| Author/Year | Study Objectives | Participants | Intervention and Outcome Measures | Results | Study Limitations |
| Michelle M. Cloutier, James Wiley, Zhu Wang, Autherene Grant and Amy A. Gorin (2015) | To find the efficacy of Early Childhood Obesity Program in increasing awareness about obesity and describe the need of behavioural change about obesity, changing children behaviour by describing the importance of exercise, nutrition and adverse effects of junk food | Participants: 57 mothers with newborn babies were targeted by awareness teams out of these 57, 27 living in the neighbourhood received only standard home visits while 30 received both Early Childhood Obesity Program and standard home visit | Intervention: Sessions with mothers about awareness of adverse effects of obesity, guidance about breastfeeding and self-assessment of family health status, and evaluated the results in wellness plan book. Outcome: Assessment of target behaviours of children, SSB consumption, solid food introduction in diet, sleep time and duration of breastfeeding | Results were obtained by analyzing data collected for Kempe Family Scale and association between team intervention and family behaviour | The study is limited due to insufficient eligibility and less number of mothers in an intervention program |
| James P. Boyle, Amanda A. Honeycutt, K.M. Venkat Narayan, Thomas J. Hoerger, Linda S. Geiss, Hong Chen, and
| To project the number of diabetes patients in US by year 2050 | Diabetes patients between 1980 and 1998 | The research was meant to extrapolate the present number of 11 million diabetec patients in year 2000 by continued disease rate and population affected by it. Outcome: The study will be evaluated by number of patients in the year 2050, the outcome can vary as various factors effect on the extrapolated graph | The study claims that number of type 1 diabetessuffering patient will be 18 million, of which 37% are due to location changes, 27% due to growth of population and 36% by increasing chances of diabetes. | The study is limited because various factors can change the results |
| P. Branscum M. Sharma (2011) | To analyse intervention outcome in Hispanic children about childhood obesity and overweight issues | The study is based on analysis of 9 interventions | Intervention: the intervention is a critical analysis of 5 randomized trials and four significant studies, evaluated by G*power of each intervention by calculation of Cohen’s f. Outcomes: Tables showing results of overweight children, their BMI values, and Cohen’s f value | the results were based on the collective result of 9 interventions and suggestion is made to target future interventions by including diet and physical activity of children in the study, there is a need for more specific intervention strategy | The results were limited to these interventions and many factors that should be involved in the studies are not included. |
| Atkinson, Eisenbarth, Michels (2014) | To study the effectiveness of glucose pumps and analyse what improvements are needed | Intervention: the seminar is focused to discuss current methods of diabetes prevention, its pathology and future outcomes. | Results: The study resulted in increasing people knowledge about the issue and they understood the need of prevention of diabetes to avoid complications. | No limitations. | |
| Jenni Lehtisalo, Lindström, T. Ngandu, M. Kivipelto, S. Ahtiluoto, P. Ilanne-Parikka, S. Keinänen-Kiukaanniemi, J. G. Eriksson, M. Uusitupa, J. Tuomilehto, J. Luchsinger (2016) | To investigate the relation of physical activity and obesity in the participants of diabetes prevention study in finland, which is a successful intervention related to diabetes topic | 522 adults of ages above 50, total 364 took part in the asssessment | Intervention: The intervention was conducted in 5 research centers in findland, whith their annual health report, diet, and exercise routine were analysed in intervention. the evaluation will be done by analyzing the controlled diabetes cases after the intervention. | The study is expected to decrease diabetes complication cases by average 13 years time after intervention. various factors like high BMI index and less exercise became a cause of worse cases of diabetes. | The study is limited for participants of Finland. |
| Amy A Gorin, James Wiley, Christine McCauley Ohannessian, Dominica Hernandez, Autherene Grant and Michelle M Cloutier (2014) | The purpose of the study is to promote awareness about obesity, and efficacy of Steps to Growing Up Healthy program in prevention of obesity | 150 mothers and children of Latin and the Black community | Intervention: the intervention was focused on these two ethnicity groups, the evaluation will be done by the opinion of these groups on whether they benefited or not from the intervention, the evaluation of the program will be done by Reach, Effectiveness, Adoption, and Implementation criteria. Outcome: The twelve-month analysis shows decreased BMI index in the children and changed concepts about obesity, children are assessed based on their height to weight ratio, exercise and diet, whereas mothers are assessed based on their feeding practices | The results will be calculated based on the behaviour change of groups about obesity and regression analysis of attitudes of people about increased BMI index. | The study observes behaviour in children of very limited range and two groups that are in the minority |
| Bruce A. Perkins, David Z.I. Cherney, Helen Partridge1, Nima Soleymanlou, Holly Tschirhart, Bernard Zinman, Nora M. Fagan, Stefan Kaspers, Hans-Juergen Woerle, Uli C. Broedl and Odd-Erik Johansen (2014) | Thepurpose of this research is to analyse effectiveness of SGLT2 in controlling hyperglycemia of type 1 diabetes patients. | 40 participants were given 25mg of the medicine daily | Intervention: the study was meant to check the effectiveness of SGLT2 compound and will be evaluated by decreased glycemia levels in patients. Outcome: The trial decreased production of glycemia drastically and thus can be concluded effective for control of diabetes. | The glucose level decreased from 9 to 7 with upto 4 mmol/L tolerance in all patients. however the urinary excresion of glucose decreased by 220 gram/day. | No limitations |
| Susanne Famulla, Ulrike Hövelmann, Annelie Fischer, Hans-Veit Coester, Lidia Hermanski, Matthias Kaltheuner, Lars Kaltheuner, Lutz Heinemann, Tim Heise and Laurence Hirsch (2016) | The objective of this study is to find the effect of lipohypertrophy and its impact on insulin absorbtion. | 13 patients suffering with type 1 diabetes. | Intervention: The study was performed by injecting low dosage of LHT in patients, the evaluation will be done by measuring insulin levels in patoents. Outcome: This study successfully proved decreased hyperglycemia and LHT is found to effective as a control agent | Results: The level of insulin decreased in the body after LHT injection proving effectiveness of the compound. | The study has small sample size of 13 patients. and the repeated control of insulin by clamp and MMTT. |
| Dr Steven A Grover, Mohammed Kaouache, Philip Rempel, Lawrence Joseph, Martin Dawes, David C W Lau, IlkaLowensteyn (2015) | To develop a disease simulation model to estimate the annual risk of mortality, and cardiovascular disease in diabetes patients | 3992 non-Hispanic people. | Intervention: The study is aimed to calculate risk factor of cardiovascular disease and mortality rate. Outcome: the study proved useful in debate between diabetes and its effects on patients leading to cardiovascular diseases. | Excess BMI index has relation with increased rate of mortality and cardiovascular problems. | Hispanic population only |
| Rodica Pop-Busui, Andrew J.M. Boulton, Eva L. Feldman, Vera Bril, Roy Freeman, Rayaz A. Malik, Jay M. Sosenko and Dan Ziegler (2017) | To analyze neuropathic problems related to type 1 diabetes and measure its severity level | Japanese patients who are early diagnosed with type 1 diabetes | The research is analyzing autonomic and cardiovascular neuropathy and can be evaluated by calculating data related to neuropathic complexities in diabetic patients
| Results: The set of studies showed relation of diabetes with neuropathic problems | No Limitations |
References
Atkinson, Mark A., George S. Eisenbarth, and Aaron W. Michels. “Type 1 diabetes.” The Lancet 383.9911 (2014): 69-82.
Boyle, James P., et al. “Projection of diabetes burden through 2050: impact of changing demography and disease prevalence in the US.” Diabetes care 24.11 (2001): 1936-1940.
Branscum, P., and M. W. Sharma. “A systematic analysis of childhood obesity prevention interventions targeting Hispanic children: lessons learned from the previous decade.” Obesity Reviews 12.5 (2011).
Cloutier, Michelle M. et al. “The Early Childhood Obesity Prevention Program (ECHO): An Ecologically-Based Intervention Delivered By Home Visitors For Newborns And Their Mothers.” BMC Public Health, vol 15, no. 1, 2015, Springer Nature, doi:10.1186/s12889-015-1897-9.
Famulla, Susanne, et al. “Insulin injection into lipohypertrophic tissue: blunted and more variable insulin absorption and action and impaired postprandial glucose control.” Diabetes Care 39.9 (2016): 1486-1492.
Gorin, Amy A et al. “Steps To Growing Up Healthy: A Pediatric Primary Care Based Obesity Prevention Program For Young Children.” BMC Public Health, vol 14, no. 1, 2014, Springer Nature, doi:10.1186/1471-2458-14-72.
Grover, Steven A., et al. “Years of life lost and healthy life-years lost from diabetes and cardiovascular disease in overweight and obese people: a modelling study.” The lancet Diabetes & endocrinology 3.2 (2015): 114-122.
Lehtisalo, Jenni, et al. “Association of long-term dietary fat intake, exercise, and weight with later cognitive function in the Finnish Diabetes Prevention Study.” The journal of nutrition, health & aging 20.2 (2016): 146-154.
Perkins, Bruce A., et al. “Sodium-glucose cotransporter 2 inhibition and glycemic control in type 1 diabetes: results of an 8-week open-label proof-of-concept trial.” Diabetes care 37.5 (2014): 1480-1483.
Pop-Busui, Rodica, et al. “Diabetic neuropathy: a position statement by the American Diabetes Association.” Diabetes care 40.1 (2017): 136-154.
