Crohn’s Disease essay
A nurse needs to take many factors into considerations before administering to any patients. First, I need to check Jordan for any interactions with drug or herbs. According to Wang et al. 2016), pethidine is known to be both physically or chemically incompatible with thipentone solutions or any solution that contains heparin sodium, morphine sulphate, ivarubicin hydrochloride, sodium bicarbonate, sulphafurazole diethanolamine, frusemide or acyclovir sodium. Also, pethidine is incompatible with iodine, iodide and alkalis. Furthermore, it is vital to check Jordan for any allergies because it has cough reflex action cause pethidine’s depressant effect (Wang et al., 2016). Finally, assessing Jordan’s mental status and suicidal tendencies is critical to the well-being of the patient. Pethidine is characterised by its depressant effect on the central nervous system hence causing drowsiness, depression and general impairment of coordination. Hence, assessing the mental health and suicidal tendencies gives the nurse ideas on how to administer the doses depending on the results of the assessment. Mental changes such as anxiety, hallucinations, poor concentration and agitation has been reported in some cases when administering pethidine.
During administration of pethidine, various interventions need to be considered to ensure that Jordan gets better without much effects from the medicine. Iversen, 2016 states that “the nurse should keep opioid and antagonist and facilities for assisted or controlled respiration readily available during parenteral administration and, also, when injecting subcutaneously into chilled areas of the body, or patients in shocks.” The reason for this is because impaired perfusion is known to cause delay in absorption (Iversen, 2016). Iversen further states that the doses in such cases, usually, excessive amount of pethidine is absorbed when blood circulation is restored to its normal state. During the period Jordan is receiving, reassuring him that addiction to pethidine is unlikely, because “most patients who are receiving opiates for medical reasons are known not to develop any dependence syndromes” (Iversen, 2016).
After administering pethidine, the nurse should monitor the effectiveness of the medicine by observing decrease in the symptoms of the disease. Decrease in the symptoms of the diseases means that the dosage is effective and if otherwise, the nurse can think of changing the dosage. Also, monitoring the side effects ensures that Jordan recovers at the best pace and hence avoiding the effects that is associated with the side effects such as accidents. The nurse should also advise the patient on the safety precautions to avoid getting reinfection and deal with the after-effects of taking the drug.
Ramadas et al., 2010 describes Crohn disease “as an idiophantic, chronic inflammatory process that affects any part of the gastrointestinal tracts from the mouth to the anus”. It is characterised by periods of symptomatic relapse and remission experienced by the patient (Ramadas et al., 2010). It is a bowel inflammatory disease that causes signs and symptoms of the pain in abdomen that causes frequent empty of intestines causing diarrhoea. The symptoms of Crohn’s disease are bloating constipation, or pain or bleeding when moving the bowel.
“Although the cause of Crohn’s disease is still unknown, some scientists suspect that strains of bacteria such as mycobacterium causes the infection” (Ramadas et al., 2010). On activation of the immune system in small intestines, there is inflammation caused in the tissues where activation occurs. Individual with IBD experience immune system is activated without any harmful invader resulting in chronic inflammation and ulceration. “During the initial stages Crohn’s disease cause small, scattered, shallow, crater-like erosions on the inner surface of the bowel” (Ramadas et al., 2010). With time, the erosions becomes deeper and larger turning into real ulcers, that causes scarring and stiffness of the bowel. Ultimately, the bowel becomes narrower and obstructed causing perforations in the walls of the bowel, and bacteria that infect adjacent organs and the surrounding abdominal cavity (Ramadas et al., 2010). The obstruction is responsible for the loss of weight by Jordan because it causes obstruction of food, fluid and gas from stomach and small intestine into colon. Obstruction causes nausea and vomiting meaning that there is no enough diet for Jordan to build his body. “With development of puncture holes in the walls of intestine, creating a tunnel between the intestine and the adjacent organ causing collection of infected pus forming abdominal abscess”(Ramadas et al., 2010).
According to García-Muñoz et al., (2014), methylprednisolone is a derivate of prednisolone that has similar anti-inflammatory action. The chemical formula of methylprednisolone is C22H30O5 and has the molecular weight of 374.477 g/mol. It is a corticosteroid which mechanism of action is as a corticosteroid hormone receptor agonist. Methylprednisolone is described a synthetic corticosteroid characterised by their anti-inflammatory and immunomodulation properties. Methylprednisolone acts by binding to and activating specific nuclear receptors that results in altered gene expression and inhibiting the production of proinflammatory cytokine. These specific nuclear receptors results in decrease in the number of circulating lymphocytes, induce cell differentiation, and finally stimulation of apoptosis in the populations of the sensitive tumour cell. For patients with oedema such as Jordan, methylprednisolone is important so as to avoid rebound increase in intracranial pressure. This helps reduce the fistula caused by Crohn’s disease. The pressure is reduce by action of methylprednisolone that separates the glucocorticoid and mineralocorticoid effect resulting in reduced incidence of sodium and water retention.
References
García-Muñoz, R. A., Morales, V., Linares, M., González, P. E., Sanz, R., & Serrano, D. P. (2014). Influence of the structural and textural properties of ordered mesoporous materials and hierarchical zeolitic supports on the controlled release of methylprednisolone hemisuccinate. Journal of Materials Chemistry B, 2(45), 7996-8004.
Iversen, L. (Ed.). (2013). Drugs of abuse. Springer Science & Business Media.
Ramadas, A. V., Gunesh, S., Thomas, G. A. O., Williams, G. T., & Hawthorne, A. B. (2010). Natural history of Crohn’s disease in a population-based cohort from Cardiff (1986–2003): a study of changes in medical treatment and surgical resection rates. Gut, 59(9), 1200-1206.
Wang, Q., Wang, L., Sheng, K., Zou, L., Li, G., & Ye, B. (2016). A simple and sensitive method for determination of tetrahydropalmatine based on a new voltammetric sensor. Talanta, 161, 238-244.
